Termination of the first trimester pregnancy in women gravida,
pre-treated with misoprostol
M. Panova, K. Nedialkov
Department of Gynecology, First Ob-Gyn Hospital, St.Sofia,
Sofia, Bulgaria
The aim of this study is to compare efficacy and complications
associated with early pregnancy termination in women pretreated with misoprostol.
Material and method: Patients G1 pregnant in first
trimester were allocated in two groups: 43 women pre-treated with 200mkg
misoprostol waginaly two times–12h and 2h before procedure and 43 women
without medications. Pregnancy termination was performed by dilatation and
aspirations. We evaluated cervical status/need for dilatation /, blood lose,
operative time and late complications-blood and ova part retention. All 86
patients were gravida1 and there were no significant differences in age and
physical status.
Results: In the group with medication 38 patients had 9mm
dilatation and do not need additional dilatation, 4 had 6mm dilatation and need
to 9mm dilatation and1 needed complete dilatation. In the group without
medication all patients except 4 needed complete dilatation. Operative time in
the first group was 5 min (range 3,5–7), in the group without medication –8
min (range 5,5–10) (p50,05). Blood lose in both groups was the same. In the
group with medication 5 patients had haematometra (blood retention in the 3 day
after procedure)–11,6%, in the second group 15 patients had blood retantion–34,8%
(P50,05).
Conclusion: We found that pre-treating patients with
misoprostol and following aspiration of concept is effective and safe method for
termination of first trimester pregnancies especially in women gravida1.
