Effect of Implanon® on serum lipids, liver function tests and hemoglobin levels

Effect of Implanon® on serum lipids, liver function tests and hemoglobin


B. Dilbaz, O. Ozdegirmenci, E. Caliskan, S. Dilbaz, S. Gungor, A. Haberal

Department of Obstetrics and Gynaecology, SSK Maternity and Women’s

Health Teaching Hospital, Ankara, Turkey

Introduction: Implanon® is a single rod, 4 cm in length and 2 mm in

diameter, containing approximately 68 mg of etonogestrel in a polyethylene vinyl

acetate copolymer membrane. Published studies about the effects of Implanon® on

lipid, liver function metabolism and hemoglobin levels are limited.

Aims and methods: This prospective study aimed to assess the possible

effects of Implanon® on serum lipids, liver function tests and hemoglobin

levels over a 6-month period. A total of 82 healthy volunteers of childbearing

potential, aged 19 to 41 years, were enrolled in the study. Serum concentrations

of total cholesterol (TC), triglycerides (TG), high-density lipoprotein

cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very

low-density lipoprotein cholesterol (VLDL-C), aspartate aminotransferase (AST),

alanine aminotransferase (ALT) and hemoglobin (Hb) levels were tested before and

at 6 months after insertion. Baseline mean parameters were compared with mean

parameters at 6 months for statistical significance using paired samples t test.

Results: Mean age of the patients was 27.5+4.8 years. The mean

duration of time from their last pregnancy was 24.3+37.3 months. The

gravidity and the parity of the patients were ranging from 1 to 8 and from 0 to

3, respectively. All the baseline parameters tested were within the laboratory

reference ranges. Mean changes in TC, HDL, ALT and Hb levels were statistically

significant. Baseline mean TC and HDL levels were 166.63 and 50.2 mg/dl and

decreased to 153.91 and 43.04 mg/dl 6 months later, respectively, which were

statistically significant (p=0.001, p=0.000). Although mean TG, VLDL and LDL

concentrations tended to decrease during the study, these slight decreases from

baseline levels were nonsignificant. An increase in mean ALT level was observed

at 6 months which was statistically significant (p=0.03). Mean baseline value of

ALT was 17.9 mg/dl and 20.9 mg/dl at 6 months. A slight increase was also seen

in mean AST levels but this increase was not nsignificant (p=0.1). Statistically

significant elevations in Hb levels were observed (p=0.03). Baseline mean value

of Hb was 13.23 g/dl. It increased to 13.59 g/dl at 6 months.

Conclusion: Implanon® has a positive effect on hemoglobin and TC

levels. Although a decrease in HDL-C was observed, this change was not a serious

concern as HDL-C did not fall a risky values.

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