Efficacy and cycle changes of emergency contraception with levonorgestrel with women at different ages

Efficacy and cycle changes of emergency contraception with levonorgestrel

with women at different ages

G. Kolarov (1), T. Chernev (1), S. Georgiev (1), B. Pehlivanov (2)

University Hospital of Obstetrics and Gynecology ‘Maichin Dom’, Sofia,

Bulgaria (1); Medical University, Department of Obstetrics and Gynecology,

Plovdiv, Bulgaria (2)

Objectives: There exists certain reservation in prescribing emergency

contraception (EC), mainly for fear of possible occurrence of disturbances in

the menstrual cycle (MC). This applies particularly to the fear of prescribing

such a type of contraception to teenagers. For these specific reasons, the

present study aims to assess the efficacy of EC with Levonorgestrel (LNG) and

the possible cycle changes after its use by women from different age groups.

Design & Methods: The study is an open-label one, including 158

(n=158) healthy, non-pregnant women, with regular menstrual cycle. The subjects

were divided into three groups. The first group – G1 included 52 girls aged

between 16 and 19 years. The second group – G2 included 55 women aged between

20 and 25 years. The third group – G3 includes 51 women aged between 26 and 30

years. All subjects have had one unprotected or faultily protected sexual

intercourse. All of the women participating in the study had administered 0.75

mg LNG within the immediately following 72 hours. The same dosage was

administered repeatedly 12 hours after the first intake. The efficacy of the EC

has been estimated following Dixon’s method. Variational analysis has been

applied for processing the data obtained from the study.

Results: A single pregnancy was registered in each of the three

surveyed groups, amounting to pregnancy rate – 1.92 %, 1.82% and 1.96%,

respectively. There were not significant differences in the efficacy rate in the

three groups – G1 (78.76 %), G2 (80,38 %) and G3 (79.61), respectively. The

ratio of women with unchanged cycle in the groups is – G1 51.92 %, (G2) –

56.36 % and G3 – (54.59). No significant differences conditioned by the

different age range of the three groups were registered in the menstrual cycle

changes and the length of bleeding.

Conclusions: Emergency contraception with LNG provides effective

contraception without serious changes in the menstrual cycle irrespective of age

differences as the results in all three studied groups show.

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