The research of the gonadotropic hormones and prolactin levels in young
women while using lowdosed combined oral contraceptives
L.V. Suturina, L.F. Sholokhov, A.V. Labigina, L.M. Lazareva, O.J.
Leshenko, N.L. Shagina, T.L. Kazakova, N.M. Jatskevitch, E.V. Galchenko
Scientific Center of Medical Ecology of East Siberian Scientific Center of
Siberian Branch, Irkutsk, Russia
Aims and methods: For the research of the gonadotropic hormones and
prolactin concentrations while using low-dosed combined oral contraceptives 156
healthy women of young reproductive age (21.6+3.1 years old) , who asked
to select a method of contraception and who had been selected casually, were
examined. The levels of LH, FSH and prolactin were defined by radioimmunological
method in all women before using contraceptives and during contraception.
Results: While defining basal concentrations of the researched
hormones it was stated, that the middle levels of LH in women, who begin
contraception, do not come over the age norms, while this in 58 women (24 %) the
LH level was moderately raised with LH/FSH42, and in 3 patients (1.9 %) the
reduce of LH concentration was defined. In 1–3 months during contraception
there were not defined any in the whole statistically significant differences of
LH concentrations in the group, but the tendency to reduce of LH/FSH level while
its initial increasing was marked. The middle basal concentrations of FSH were
3.4+2.1 mUI/l. In 6 women (3.8 %) the FSH level came over the upper norm
line (11.7+0.2 mUI/l), in 36 (23 %) it was decreased (1.2+0.8 mUI/l).
During contraception in the middle any statistically significant differences of
FSH concentrations were not defined, but while initial reduction of the FSH
level the same as its normalization and reduction were marked. Among women
beginning using hormone contraceptives in 10 % cases (in 16 patients)
hyperprolactenemy was defined (the middle level of prolactin was 1035+200
mUI/l), but in one month after beginning of contraception the increased level of
prolactin were marked only in 2 % women, that let in the majority of cases to
observe the initial increase of prolactin as casual, not demanding correction or
abolition of COC.
Conclusion: The given results of the research of gonadotropines and
prolactin levels in young women taking low-dosed hormone contraceptives during 1–3
months, say about the absence of limitations of continuing using COC in the
majority of tested women. (The further dynamic research in 6 and 12 months is
planned).
