Effects of a monthly injectable contraceptive (Cyclofem) on menstrual
pattern and lipoprotein profile
F. Ramezani Tehrani (1), Z. Hashemi (2), N. Peykari (3), Sh. Djalalinia (4)
Associated professor, National Research Center for Reproductive Health
(1); Gazvin Medical University (2); National Research Center For Reproductive
Health (3); National Research Center For Reproductive Health (4)
Objectives: The objective of this study was to determine the effects
of a combine once- a -month injectable contraceptive on menstrual pattern and
lipoprotein profile.
Method: 35 women aged 20–39 who would like to use injectable
contraception without any previous history of abnormal uterine bleeding or
hyperlipidemia were included. In the follicular phase of pre injection cycle the
lipoprotein parameters were determined, also asked them to complete menstrual
cards for identification of their pre injection status.
Results: The same serum lipid measurements were repeated after 3, 6
and 9-month injections and their monthly menstrual cards were collected for
determination of their menstrual pattern. At the end of 9 months about 2/3 of
subjects has normal menses but 5 women discontinued earlier. Serum cholesterol,
LDL, and Triglyceride did not have significant change, but HDL and VLDL
decreased significantly at 3 month with maintenance through the other months.
Conclusion: Cyclofem was well acceptable with a few side effects and
without any clinically significant changes on lipoprotein parameters. It is
suggested to introduce in our family planning program.
