Using Drosperinon-containing contraceptive by women with hyperandrogenia.
L. Karakhalis, O. Fedorovich, N. Kovtun
Kuban Medical University, Krasnodar, Russia
Prescription of oral contraceptives today put into the practice their
additional advantages.
Objective The aim of our study was to estimate antiandrogenic effect
of Drospirenon-containing oral contraceptive.
Materials and methods Thirty reproductive age women with clinical
manifestations of hyperandrogenia (fat skin and hair, atypical hair growth,
acne, etc) were examinated before treatment and after 6 month of using
drosperinon-containing oral contraceptive – Yarina ® (Yasmin®). We estimated
their clinical status and hormonal changes (levels of LH, FSH,
17-hydroxiprogesteron, cortisol were measured).
Results All women noted good tolerance of Yarina®, and decreasing
clinical manifestations of hyperandrogenia. We didn’t found significant changes
FSH level (4.43±0.4 mIU/ml before treatment vs. 5.39±0.4 mIU/ml after
treatment), and LH level (11.17±1.27 mIU/ml vs. 10.7±0.78 mIU/ml). Significant
decrease of cortisol level (233.9±17.1ng/ml vs. 169.3±8.5 ng/ml; p<0.005) and 17-hydroxiprogesteron level were found (1.84±0.12 ng/ml vs. 1.3±0.08 ng/ml; p<0.001).
Conclusion Antiandrogenic effect of drosperinon-containing oral
contraceptive permit to use it for therapeutic goals by hyperandrogenic women of
reproductive age.