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Clinical experience, acceptability and effects of implanon on biochemical, hematological, hemostatical and hormonal parameters: during the first 6 months of insertion - contraception-esc.com

Clinical experience, acceptability and effects of implanon on biochemical, hematological, hemostatical and hormonal parameters: during the first 6 months of insertion

Clinical experience, acceptability and effects of implanon on

biochemical, hematological, hemostatical and hormonal parameters: during the

first 6 months of insertion 

B Yildizbas, H.G Sahin, A Kolusari, E Erdemoglu, S

Zeteroglu, M Kamaci 

Yuzuncu Yil University, Med Faculty, Obs & Gyn.

Department, Van, Turkey 

Objective Menstrual and nonmenstrual side effects,

changes in blood pressure, BMI, biochemical, hematological, hemostatical,

hormonal parameters, endometrial thickness, follicle number and maximum follicle

diameters were aimed to be assessed. 

Design and methods Forty one healthy

women, aged between 15-49 years, who preferred to use the implant were included

in the study between June 2004 and May 2005. The implant was inserted between

days 1 and 5 of their menstrual period. Findings before and 6 months after

insertion were recorded. Statistical analysis was performed using SPSS package

programme and paired samples- T test. 

Results At the sixth month of the study

no pregnancy was determined. With regard to the 90 day reference period, 7.3 %

of the patients had regular periods, 34.1 % had complaint of amenorrhea, 4.9 %

had infrequent bleeding, 7.3 % had frequent bleeding, 17.1 % had irregular

bleeding and 29.03 % had prolonged bleeding. Rate of dysmenorrhea decreased

significantly from 41.5 % to 2.4 %, complaint of mastalgia increased

significantly to 12.2 % of the patients. Mood changes appeared in 17.1 % of

patients. Acne appeared in 26.8 %. Of the laboratory, tests of the protein C

level, total cholesterol level and, estradiol level decreased significantly.

Maximum follicular diameter, follicular number and endometrial thickness

increased significantly and 19.5 % of the patient applied to remove the implant

for irregular bleeding (75 %) depressive symptoms requiring treatment (12.5 %)

and weight gain (12.5 %). 

Conclusions Implanon is safe, highly effective, but

because of irregular bleeding discontinuation rate in 6 months is high (19.5 %)

among the women in this region.

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