Clinical experience, acceptability and effects of implanon on
biochemical, hematological, hemostatical and hormonal parameters: during the
first 6 months of insertion
B Yildizbas, H.G Sahin, A Kolusari, E Erdemoglu, S
Zeteroglu, M Kamaci
Yuzuncu Yil University, Med Faculty, Obs & Gyn.
Department, Van, Turkey
Objective Menstrual and nonmenstrual side effects,
changes in blood pressure, BMI, biochemical, hematological, hemostatical,
hormonal parameters, endometrial thickness, follicle number and maximum follicle
diameters were aimed to be assessed.
Design and methods Forty one healthy
women, aged between 15-49 years, who preferred to use the implant were included
in the study between June 2004 and May 2005. The implant was inserted between
days 1 and 5 of their menstrual period. Findings before and 6 months after
insertion were recorded. Statistical analysis was performed using SPSS package
programme and paired samples- T test.
Results At the sixth month of the study
no pregnancy was determined. With regard to the 90 day reference period, 7.3 %
of the patients had regular periods, 34.1 % had complaint of amenorrhea, 4.9 %
had infrequent bleeding, 7.3 % had frequent bleeding, 17.1 % had irregular
bleeding and 29.03 % had prolonged bleeding. Rate of dysmenorrhea decreased
significantly from 41.5 % to 2.4 %, complaint of mastalgia increased
significantly to 12.2 % of the patients. Mood changes appeared in 17.1 % of
patients. Acne appeared in 26.8 %. Of the laboratory, tests of the protein C
level, total cholesterol level and, estradiol level decreased significantly.
Maximum follicular diameter, follicular number and endometrial thickness
increased significantly and 19.5 % of the patient applied to remove the implant
for irregular bleeding (75 %) depressive symptoms requiring treatment (12.5 %)
and weight gain (12.5 %).
Conclusions Implanon is safe, highly effective, but
because of irregular bleeding discontinuation rate in 6 months is high (19.5 %)
among the women in this region.