Features of hemostasis at the pregnant woman with urogenital
mycoplasmosis
I.Y. Fofanova, V.N. Prilepskaya
Research Center of Obstetrics, Gynecology
and Perinatology, Moscow, Russia
Background Genital mycoplasmas – especial group of
microorganisms causing various diseases in the adults and infants. The presence
of genital mycoplasmas often accociate with urogenital inflammatory pathology,
complications of pregnancy, pathology of fetus and newborn. Pathogenesis of
complications, caused by mycoplasmas is unsufficiently investigated. In this
connection we investigated features of system of hemostasis at the pregnant
woman with urogenital mycoplasmas.
Material and methods A total of 132 pregnant women with
urogenital mycoplasmas in term 8-12 and 18-20 weeks of pregnancy were surveyed.
Urogenital mycoplasmas (U.urealyicum, M.hominis) are revealed by a PCR method in
scrape from cervix uteri. We investigated all pregnant women for antibodies to
hCH , level of fibrinogen in plasma of blood, aggregation of platelets.
Results
In term 8-10 weeks of pregnancy antibodies to hCH (IgM and/or IgG) were found at
81 (61,4 %) of pregnant women. The level of fibrinogen in early terms of
pregnancy at 83 (62,9 %) patients corresponded to norm (3,5 ± 0,42), in 49
(37,1 %) supervision was on the top border ( 4,47 ± 0,34). Aggregation of
platelets to ADF in term 8-10 weeks exceeded norm in 88 (66,7 %) supervision,
making on the average 63,8±1,8 %. In term of pregnancy 18-20 weeks at 119 (90,2
%) pregnant women in plasma of blood were found out antibodies to hCH, the level
of fibrinogen was on the top border of norm or exceeded it in 94 (71,2 %)
supervision, arrange on the average 4,56 ± 0,56. Aggregation of platelets to
ADF at 93 (70,5 %) of the women also exceeded norm.
Conclusion The presence of
urogenital mycoplasmas at pregnancy, on our data, is associated with progressing
increase of a level of fibrinogen , raised aggregation of platelets from early
terms of pregnancy. Besides by 18-20 weeks of pregnancy in most cases in plasma
of the pregnant women with urogenital mycoplasmas the antibodies to hCH were
determined, that assumes the autoimmune character of process.