Deprecated: Creation of dynamic property Permalink_Manager_Class::$permalink_manager_uris is deprecated in /var/www/contraception-esc.com/wp-content/plugins/permalink-manager-pro/permalink-manager.php on line 137

Deprecated: Creation of dynamic property Permalink_Manager_Class::$permalink_manager_permastructs is deprecated in /var/www/contraception-esc.com/wp-content/plugins/permalink-manager-pro/permalink-manager.php on line 138

Deprecated: Creation of dynamic property Permalink_Manager_Class::$permalink_manager_redirects is deprecated in /var/www/contraception-esc.com/wp-content/plugins/permalink-manager-pro/permalink-manager.php on line 139

Deprecated: Creation of dynamic property Permalink_Manager_Class::$permalink_manager_external_redirects is deprecated in /var/www/contraception-esc.com/wp-content/plugins/permalink-manager-pro/permalink-manager.php on line 140

Deprecated: Creation of dynamic property Permalink_Manager_Class::$permalink_manager_alerts is deprecated in /var/www/contraception-esc.com/wp-content/plugins/permalink-manager-pro/permalink-manager.php on line 145
Study on the effects of a single implant containing nomegestrol acetate (UNIPLANT) on the hormonal profile, endometrial morphology and ultrasonographic evaluation of ovarian function - contraception-esc.com

Study on the effects of a single implant containing nomegestrol acetate (UNIPLANT) on the hormonal profile, endometrial morphology and ultrasonographic evaluation of ovarian function

Study on the effects of a single implant containing nomegestrol acetate (UNIPLANT)

on the hormonal profile, endometrial morphology and ultrasonographic evaluation

of ovarian function

I.C. Barbosa, H. Maia Jr, R. Lopes, A.C.V. Lopes, E.M. Coutinho

Department of Gynecology, Obstetrics and Human Reproduction, Federal

University of Bahia, Salvador, Bahia, Brazil

Objectives: The objective of this study was to evaluate the effects of

a single silastic implant containing 55 mg+10% of nomegestrol acetate on

the hormonal profile, endometrial morphology, cervical mucus, maturation index

and evaluation of ovarian function by vaginal sonography, during one year.

Material & Methods: Twenty healthy women of reproductive age (18–30

years old) participated in this study. Prior to implant insertion, a clinical

examination was carried out, which included: a general medical and gynecological

examination, as well as the collection of cervical/vaginal material for cytology

and maturation index. Hysteroscopy with endometrial biopsy was carried out

during the control cycle in all patients. All patients were submitted to a

second hysteroscopy during the study, five during the second month of use, five

during the sixth month and ten during the twelfth month of UNIPLANT use. In the

same cycle in which hysteroscopy was performed, hormone measurement, vaginal

sonography and cervical mucus collection was carried out thrice weekly.

Results: Based on levels of plasma progesterone, 80% of cycles studied

in users of UNIPLANT were anovulatory. In 56% of cycles, the presence of

persistent, non-luteinized follicles was observed. Cervical mucus was evaluated

according to criteria established by the World Health Organization and showed a

marked reduction during treatment cycles in all parameters studied. Endometrial

thickness was <8 mm in all treated cycles in the study. Alterations in the endometrial architecture were observed in the majority of treated cycles and consisted of the presence of a thin endometrium with a marked increase in vascularization.

Conclusion: This study demonstrates that UNIPLANT is a long-acting

contraceptive method that probably functions at hypothalamic-hypophyseal level,

on the ovary, the endometrium and in cervical mucus production.

Scroll to Top