Our experience with Diane-35 in the treatment of acne

Our experience with Diane-35 in the treatment of acne

J. Georgievska, S. Popovska

Clinic for Gynecology and Obstetrics, Medical faculty Skopje, R Macedonia

Introduction: Because sex steroids, produced both from the ovaries and

from the adrenals, are involved in the development of acne, suggesting increased

androgen activity/sensitivity as an aetiological factor, antiandrogenic drugs

have been used for the treatment of acne. The most potent antiandrogen is

estrogen, with increasing sex hormon binding globulin (SHBG) levels. Other

antiandrogen is cyproterone acetate (CPA). CPA is a derivative of

hydroxyprogesterone and acts as a progestogen and as an antiandrogen. CPA has

been used in combination with different doses of EE for the treatment of acne

and androgenic disorders.

Objective: The aim of this study was to evaluate the effect of

combined oral contraceptive Diane 35 (0.035mg EE/2 mg CPA) in women with mild

and moderate acnae vulgaris and seborrhoea (n=50) against placebo group (n=30)

for period of six months. Materials and methods: We investigated 50 patients

with mild and moderate acne vulgaris treated on our Clinic for Gynecology and

Obstetrics during the 2003. All of them received Diane 35 for the treatment of

acne after complete investigations. They were controled after 3 and 6 months of

treatment. Patients were assessed for the severity of symptoms of acne by

grading, lesion comit and photography. Also hormon and lipid levels were


Results: The mean age of users (+SD) was 22,5+5,1 years

of the women aged between 15 and 25years. After six months of treatment with

Diane 35, we have found clinical improvement in the treatment group with

reduction in the number and severity of lesions. We have found decrease in

dehydroepiandrosterone sulphate levels (DHEA-S) in 60%, whereas total

testosterone did not decrease. Seborrhea decreased in 25%. We have found

increase in triglyceride levels with decrease in the levels of LDL-c.

Conclusion: Good improvement of acne vulgaris follows treatment with

Diane 35. Therefore, although acne is not the primary indication for combined

OCPs, it seems reasonable to use this preparations to women suffering from acne,

particularly if they also require a contraceptive method.

Scroll to Top