Prophylaxis of side effects of hormonal contraceptive
Magne-B6
V.N. Prilepskaya, N.M. Nazarova, E.A. Mejevitinova
Research Center of
Obstet., Gynec and Perinat, Moscow, Russia
Objectives Study of Magne-B6 effect
on adaptational features in women during oral contraception use.
Materials and methods One hundred and fifty somatically healthy women
(18 – 39 years old) having no
contraindications to OC. Group 1 consisted of 75 women who used low-dose OC
containing 30mcg ethinylestradiol and 150 mcg desogestrel, group 2 included 75
women using Magne-B6 during 2-3 months. Along with clinical methods of study
arterial pressure and body mass were measured, blood tests for hemostasis, blood
lipid spectrum, extended colposcopy, cytological tests, ultrasound examinations
were applied.
Results Side effect were registered in 28% (22) of women of group
1 and in 13.3% (10) in group 2. The most frequent side effects in the 1st group
were as follows: mastalgia (10.6%), mastodynia (10.6%), intramenstrual discharge
(8%), anxiety (2.6%), vomiting 5.2%. Among the patients of group 2 the most
typical were intramenstrual spotting.
Conclusion The use of modern low-dose
estrogen-gestagen contraceptives simultaneously with short-term use of Magne-B6
may contribute to the decrease of side effect rate during the period of 3-months
adaptation of OC use thus improving its tolerance. Further investigations are
needed.